Calycosin stimulates the proliferation of endothelial cells, but not breast cancer cells, via a feedback loop involving RP11-65M17.3, BRIP1 and ERα
نویسندگان
چکیده
منابع مشابه
Combination of metformin and phenformin synergistically inhibits proliferation and hTERT expression in human breast cancer cells
Objective(s): Breast cancer remains a global challenge, and further chemopreventive therapies are still immediately required. Emerging evidence has revealed the potent anti-cancer effects of biguanides, Metformin (MET) and phenformin (PHE). Thus, to explore an efficient chemopreventive strategy for breast cancer, the antiproliferative effects of the combination of MET and PHE against breast can...
متن کاملInfluence of Cellular ERα/ERβ Ratio on the ERα-Agonist Induced Proliferation of Human T47D Breast Cancer Cells
Breast cancer cells show overexpression of estrogen receptor (ER) alpha relative to ERbeta compared to normal breast tissues. This observation has lead to the hypothesis that ERbeta may modulate the proliferative effect of ERalpha. This study investigated how variable cellular expression ratios of the ERalpha and ERbeta modulate the effects on cell proliferation induced by ERalpha or ERbeta ago...
متن کاملInduction of the CLOCK Gene by E2-ERα Signaling Promotes the Proliferation of Breast Cancer Cells
Growing genetic and epidemiological evidence suggests a direct connection between the disruption of circadian rhythm and breast cancer. Moreover, the expression of several molecular components constituting the circadian clock machinery has been found to be modulated by estrogen-estrogen receptor α (E2-ERα) signaling in ERα-positive breast cancer cells. In this study, we investigated the regulat...
متن کاملComparative Study of Anti-Cancer Properties of Hydroalcoholic Extract of Different Cultivars of Apricot Kernels on Breast Cancer Cells (MCF7) and Human Umbilical Vein Endothelial Cells
Background and purpose: Breast cancer mortality is growing around the world due to chemotherapy resistance and chemo-related side effects. Many natural products from plants are recognized to exert anticancer activity. This study aimed at investigating anti-proliferative and apoptotic activity of hydro-alcoholic extract of different varieties of apricot kernels (Jahangiri, Palmia, Jafari, and N5...
متن کاملEffects of FSTL1 on the proliferation and motility of breast cancer cells and vascular endothelial cells
BACKGROUND Treatments that prevent the motility of breast cancer cells and inhibit formation of new capillary vessels are urgently needed. FSTL1 is a secreted protein that has been implicated in maintaining the normal physiological function of the cardiovascular system, in addition to a variety of other biological functions. We investigated the role of FSTL1 in the proliferation and migration o...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Aging
سال: 2021
ISSN: 1945-4589
DOI: 10.18632/aging.202641